Masahiro Ono
MD PhD FHEA
Dr Masahiro Ono
Department of Life Sciences
Imperial College London
London SW7 2AZ
Masahiro Ono is an Integrative Experimental and Computational Immunologist. He is known as the creator and developer of the innovative Timer-of-Cell-Kinetics-and-Activity (Tocky) technology.
Expertise:
- Integrative Experimental and Computational Immunology
- Molecular and Systems Immunology
- Cancer Immunology
- Computational Biology for Cytometry and Genomics
Innovations and Tools:
- Developer of Tocky (とき)
- Application of Canonical Correspondence Analysis in Genomic Analysis
Current Position:
Education:
- Kyoto University, Japan
news
Nov 06, 2024 | 💻 New R Package Released – TockyPrep: We have released the TockyPrep package, which offers data preprocessing methods for Tocky data (and any Fluorescent Timer data). Such data would not be fully useful without these proper analytic methods. Our preprint is accessible here |
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Nov 05, 2024 | 💻 New R Package Released – GatingTree: A ground-breaking R package for analysing high-dimensional cytometry data without the use of dimensional reduction. 🚀 See the GatingTree website and my research paper for the details! |
Jun 13, 2024 | 📄 New Paper Published: The spectrum of self-reactive T cells and their activation mechanisms exploited by HTLV-1 infection 🔬🧬 |
Mar 25, 2024 | 🚀 A new website has launched! 🌐✨ |
latest posts
Jun 21, 2024 | The Unsung Roles of HTLV-1 in the Discovery of CD25 and Treg |
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Jun 09, 2024 | tocky illuminates mechanisms of immune checkpoint blockade |
Jun 07, 2024 | t-cell dynamics matter |
selected publications
- A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programmeThe EMBO journal, 2018The second Tocky paper from the Ono lab uncovers the temporally dynamic regulation of Foxp3 transcription, offering new insights into T cell regulation.
- A timer for analyzing temporally dynamic changes in transcription during differentiation in vivoJournal of Cell Biology, 2018The foundational publication introducing Tocky technology by the Ono lab, marking a breakthrough in T cell and B cell studies.
- Controversies concerning thymus‐derived regulatory T cells: fundamental issues and a new perspectiveImmunology and cell biology, 2016A landmark opinion piece challenging the reproducibility of a foundational Treg experiment, while introducing a groundbreaking dynamic view on Foxp3-mediated T cell regulation.
- Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulationsThe Journal of Immunology, 2016The pioneering study ntroduces a data-driven methodology to explore Treg subpopulations, employing Principal Component Analysis (PCA) for the first time.
- Visualisation of the T cell differentiation programme by Canonical Correspondence Analysis of transcriptomesBMC Genomics, 2014This study establishes CCA as a vital quantitative tool for transcriptome analysis in immunological datasets.
- Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseasesPLoS One, 2013The pioneering study developing Canonical Correspondence Analysis (CCA) as a genomics method, establishing a novel approach for transcriptome analysis.