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Last update, 2024-03-26
Basics
Name | Masahiro Ono |
Label | Immunologist |
m.ono@imperial.ac.uk | |
Url | https://www.imperial.ac.uk/people/m.ono/ |
Summary | A Japan-born immunologist, the innovator and developer of the technology Timer-of-cell-kinetics-and-activity (Tocky) |
Work
- 2015 - Current
Reader in Immunology
Department of Life Sciences, Imperial College London
Research and Teaching.
- Development of Tocky
- Research in Autoimmunity
- Cancer Immunology
- 2013 - 2015
BBSRC David Phillips Fellow
Institute of Child Health, University College London
Research
- Development of Tocky
- Flow Cytometric Data Analysis
- 2009 - 2012
Human Frontier Science Program Long-Term Fellow
Institute of Child Health, University College London
Research
- Development of Canonical Correspondence Analysis as a Genomic Method
Academic_service
- 2013 - Current
Editor
Editorial Roles
Peer reviewing various grants and manuscripts
- Discovery Immunology, Editorial Board Member
Education
Awards
- 2007
Kato Memorial Bioscience Foundation Research Award
Kato Memorial Bioscience Foundation
Awarded for enabling pioneering exploration in the fields of molecular biology and immunology in Kyoto.
- 2009
Human Frontier Science Program Long-Term Fellowship
Human Frontier Science Program
A three-year fellowship that facilitated my transition into Molecular and Systems Immunology, laying the groundwork for the conception of Tocky.
- 2013
BBSRC David Phillips Fellowship
Biotechnology and Biological Sciences Research Council (BBSRC)
A five-year fellowship awarded for establishing my inaugural laboratory at University College London, which was instrumental in the development of Tocky.
- 2021
CRUK Foundation Programme Award
Cancer Research UK (CRUK)
Six-year programme grant for cancer immunology.
Certificates
FHEA | ||
AdvanceHE | 2024 |
PhD | ||
Kyoto University | 2006 |
MD | ||
Ministry of Health, Labour and Welfare, Japan | 1999 |
Bachelor of Medicine | ||
Kyoto University | 1999 |
Publications
-
2018.07.10 A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme
EMBO Journal
The second Tocky paper, establishing Foxp3 Tocky as a method to analyse temporal changes of regulatory T cell function, identifying the autoregulatory loop of the Foxp3 gene.
-
2018.06.25 A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo
Journal of Cell Biology
The first report of the Tocky technology, establishing the transgenic lines Nr4a3-Tocky and Foxp3-Tocky and data analytic methods to analyse Timer fluorescence data.
-
2013.01.02 Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseases
PLOS ONE
The development of Canonical Correspondence Analysis as a genomic method to analyse transcriptome data in biomedical contexts, establishing quantitative measures for the degree of cellular differentiation using haematological disease datasets.
Innovations
Tocky | |
Transgenic Systems Development | |
Data Analysis: Linear Algebra and Multidimensional Analysis | |
Bioinformatics for Flow Cytometric Analysis |
Application of Canonical Correspondence Analysis (CCA) for Genomic Studies | |
Transcriptome Analysis | |
Single Cell RNA-seq Analysis |
Expertise
Immunology | |
T cells | |
Antigen signalling (TCR signalling) | |
Cancer Immunology | |
T cell development, thymus | |
T cell differentiation | |
Foxp3 and regulatory T cells |
Molecular Biology | |
Transcriptional Regulation | |
Transcription Factor | |
Protein-Protein Interaction | |
Chromatin Immunoprecipitation | |
Sequencing |
Biological Methodology | |
Multidimensional Analysis | |
Bioinformatics Analysis | |
Flow Cytometric Data Analysis | |
Genomic Data Analysis |
Dermatology | |
Dermatology Practice: 1999 - 2006 | |
Dermatological Science: 2006 - |
Skills
Immunology | |
T cell biology | |
Cancer Immunology | |
Immune Checkpoints | |
Foxp3 and regulatory T cells | |
Infection Immunology | |
Thymic Development |
Molecular Biology | |
Transgenesis | |
Transcriptional Regulation | |
Transcriptome |
Data Science | |
Multidimensional Analysis | |
Genomic Data Analysis | |
Flow Cytometric Data Analysis | |
Machine Learning |
Programming | |
R | |
Python |
Languages
Japanese 🇯🇵 | |
Native speaker |
English 🇬🇧 | |
Fluent |
Projects
- 2009 - 2012
Human Frontier Science Progam Long-Term Fellowship:
The project enabled development of skills in mathematical and computational immunology, leading to pioneering Canonical Correspondence Analysis in genomic analysis.
- Canonical Correspondence Analysis
- Multidimensional Analysis
- 2013 - 2018
BBSRC Fellowship: Elucidation of the transcriptional programme of memory T cells by a systems approach
The project investigated mechanisms underlying T cell memory and regulation, innovating the Tocky technology and utilising it to discover novel molecular mechanisms in T-cells.
- Tocky
- Transgenesis and computational algorithms
- 2019 - 2022
MRC Project Grant: Investigation of the generation and functional maturation of regulatory T cells in vivo
The project investigated mechanisms underlying regulatory T cell differentiation and function using Tocky and various molecular immunology approaches.
- Tocky
- Transgenesis and computational algorithms
- - Current
CRUK Programme Foundation Award
Elucidating molecular and cellular mechanisms underlying T-cell dysfunction and effective anti- cancer T-cell responses: towards the development of next-generation immunotherapy
- Tocky
- Cancer Immunotherapy