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Reader in Immunology

Department of Life Sciences, Imperial College London

Research and Teaching.

• Development of Tocky
• Research in Autoimmunity
• Cancer Immunology
• Integrated Experimental and Computational Immunology

BBSRC David Phillips Fellow

Institute of Child Health, University College London

Research

• Development of Tocky
• Flow Cytometric Data Analysis

Human Frontier Science Program Long-Term Fellow

Institute of Child Health, University College London

Research

• Development of Canonical Correspondence Analysis as a Genomic Method

Editor

Editorial Roles

Peer reviewing various grants and manuscripts

• Discovery Immunology, Editorial Board Member

PhD

Kyoto University, Japan

Graduate School of Medicine

• Medical Science (Immunology)

MD

Kyoto University, Japan

Medical School

• Medicine

Kato Memorial Bioscience Foundation Research Award

Kato Memorial Bioscience Foundation

Awarded for enabling pioneering exploration in the fields of molecular biology and immunology in Kyoto.

Minami Shogo Memorial Award

Japanese Dermatological Association

The most prestigious award for dermatological researchers in Japan.

Human Frontier Science Program Long-Term Fellowship

Human Frontier Science Program

A three-year fellowship that facilitated my transition into Molecular and Systems Immunology, laying the groundwork for the conception of Tocky.

BBSRC David Phillips Fellowship

Biotechnology and Biological Sciences Research Council (BBSRC)

A five-year fellowship awarded for establishing my inaugural laboratory at University College London, which was instrumental in the development of Tocky.

CRUK Foundation Programme Award

Cancer Research UK (CRUK)

Six-year programme grant for cancer immunology.

A multidimensional toolkit for elucidating temporal trajectories in cell development in vivo

Development

This study established innovative computational methods that exploit the power of Tocky technology to decipher time-dependent processes in cellular development using Canonical Correspondence Analysis and Network Analysis.

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme

EMBO Journal

The second Tocky paper, establishing Foxp3 Tocky as a method to analyse temporal changes of regulatory T cell function, identifying the autoregulatory loop of the Foxp3 gene.

A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo

Journal of Cell Biology

The first report of the Tocky technology, establishing the transgenic lines Nr4a3-Tocky and Foxp3-Tocky and data analytic methods to analyse Timer fluorescence data.

Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseases

PLOS ONE

The development of Canonical Correspondence Analysis as a genomic method to analyse transcriptome data in biomedical contexts, establishing quantitative measures for the degree of cellular differentiation using haematological disease datasets.

Human Frontier Science Progam Long-Term Fellowship:

The project enabled development of skills in mathematical and computational immunology, leading to pioneering Canonical Correspondence Analysis in genomic analysis.

• Canonical Correspondence Analysis
• Multidimensional Analysis

BBSRC Fellowship: Elucidation of the transcriptional programme of memory T cells by a systems approach

The project investigated mechanisms underlying T cell memory and regulation, innovating the Tocky technology and utilising it to discover novel molecular mechanisms in T-cells.

• Tocky
• Transgenesis and computational algorithms

MRC Project Grant: Investigation of the generation and functional maturation of regulatory T cells in vivo

The project investigated mechanisms underlying regulatory T cell differentiation and function using Tocky and various molecular immunology approaches.

• Tocky
• Transgenesis and computational algorithms

CRUK Programme Foundation Award

Elucidating molecular and cellular mechanisms underlying T-cell dysfunction and effective anti- cancer T-cell responses: towards the development of next-generation immunotherapy

• Tocky
• Cancer Immunotherapy