News_11

📄 New Preprint Published
🧭 Our new bioRxiv preprint introduces mCanonicalTockySeq, a framework that brings an experimental time anchor into single-cell transcriptomics to analyse temporal and developmental progression together.

Using the Nr4a3-Tocky Fluorescent Timer system, this study resolves signalling-linked temporal progression alongside thymocyte differentiation and shows that the learned reference structure can be transferred across species to organise human thymic single-cell data.

• Irie N, Reda O, Satou Y, Ono M (2026). Canonical Analysis of Fluorescent Timer-Anchored Transcriptomes Resolves Joint Temporal and Developmental Progression. bioRxiv. https://doi.org/10.64898/2026.03.16.711988 🔬🧬