publications
Publication – Dr Masahiro Ono is a T-cell expert and the inventor of the innovative Timer-of-Cell-Kinetics-and-Activity (Tocky) technology.
Key publications by Masahiro Ono, showcasing innovative approaches in immunological research and beyond.
2024
- A multidimensional toolkit for elucidating temporal trajectories in cell development in vivoDevelopment, Nov 2024
- TockyLocus: Quantitative Analysis Methods for Flow Cytometric Fluorescent Timer DataNov 2024
- TockyPrep: Data Preprocessing Methods for Flow Cytometric Fluorescent Timer AnalysisNov 2024
- GatingTree: Pathfinding Analysis of Group-Specific Effects in Cytometry DataNov 2024
- Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1Discovery Immunology, May 2024
- HIV-Tocky system to visualize proviral expression dynamicsCommunications Biology, May 2024
- Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky systemBiophysics and Physicobiology, May 2024
2023
2022
- CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanomaJournal for ImmunoTherapy of Cancer, May 2022
- HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune systemFront Immunol, May 2022
- Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockadebioRxiv, May 2022
- Nur77-Tempo mice reveal T cell steady state antigen recognitionDiscov Immunol, May 2022
- Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisationbioRxiv, May 2022
- Context-dependent effects of IL-2 rewire immunity into distinct cellular circuitsJournal of Experimental Medicine, Jun 2022
2021
- HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphomaThe Journal of Clinical Investigation, Jun 2021
- Retrovirus-induced leukemia–hijack of T-cell activation mechanisms revealed by single-cell analysisbioRxiv, Jun 2021
- HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphomaJournal of Clinical Investigation, Jun 2021
- Restoring control over autoimmunity by inducing Foxp3Nature Immunology, Jun 2021
- The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selectionDevelopment, Jun 2021
- T-cell dysregulation in COVID-19Biochemical and biophysical research communications, Jun 2021
- Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometrySTAR protocols, Jun 2021
- Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signalingImmunity, Jun 2021
- Kickstarting immunity in cold tumours: localised tumour therapy combinations with immune checkpoint blockadeFrontiers in Immunology, Jun 2021
- NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6Chi monocytes in pressure-overloaded heartsScience Signaling, Jun 2021
2020
- Regulatory T cells restrain interleukin-2-and Blimp-1-dependent acquisition of cytotoxic function by CD4+ T cellsImmunity, Jun 2020
- Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexesImmunology, Jun 2020
- T-cell hyperactivation and paralysis in severe COVID-19 infection revealed by single-cell analysisFrontiers in immunology, Jun 2020
- Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and durationCell reports, Jun 2020
- Mutant BRAF small molecule inhibition enhances oncolytic herpes virus immunotherapy through increased immune cell recruitment and activation in melanomaCancer Research, Jun 2020
2019
- IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammationEuropean journal of immunology, Jun 2019
- Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulationThe Journal of clinical investigation, Jun 2019
- Sonic hedgehog is a determinant of γδ T-cell differentiation in the thymusFrontiers in immunology, Jun 2019
- Distinct regulation of Nr4a receptors by NFAT and ERK signalling during T cell activationJun 2019
2018
- From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamicsClinical and Experimental Immunology, Sep 2018
- Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell AnalysisFrontiers in Immunology, Sep 2018
- A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programmeThe EMBO journal, Sep 2018The second Tocky paper from the Ono lab uncovers the temporally dynamic regulation of Foxp3 transcription, offering new insights into T cell regulation.
- A timer for analyzing temporally dynamic changes in transcription during differentiation in vivoJournal of Cell Biology, Sep 2018The foundational publication introducing Tocky technology by the Ono lab, marking a breakthrough in T cell and B cell studies.
2017
- Revealing the mechanism of regulatory T-cell generation in vivo by novel Fluorescent Timer reporterJournal of Immunology, May 2017
- The impact of environmental enrichment on the murine inflammatory immune responseJCI insight, May 2017
- FoxP3 partners upNature Immunology, May 2017
- Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modelingJournal of Allergy and Clinical Immunology, May 2017
2016
- Water resistance profile as a marker of skin barrier damage in atopic dermatitis patientsJournal of Dermatological Science, May 2016
- Sonic Hedgehog regulates thymic epithelial cell differentiationJournal of Autoimmunity, May 2016
- Impact of enriched environment on murine T cell differentiation and gene expression profileFrontiers in Immunology, May 2016
- Controversies concerning thymus‐derived regulatory T cells: fundamental issues and a new perspectiveImmunology and cell biology, May 2016A landmark opinion piece challenging the reproducibility of a foundational Treg experiment, while introducing a groundbreaking dynamic view on Foxp3-mediated T cell regulation.
- Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulationsThe Journal of Immunology, May 2016The pioneering study ntroduces a data-driven methodology to explore Treg subpopulations, employing Principal Component Analysis (PCA) for the first time.
2015
- A Zap70‐dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytesImmunology and Cell Biology, May 2015
- A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiationOncotarget, May 2015
- Follicular helper T cell signature in type 1 diabetesThe Journal of Clinical Investigation, Jan 2015
2014
- Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI modelThe Journal of Investigative Dermatology, Jan 2014
- Visualisation of the T cell differentiation programme by Canonical Correspondence Analysis of transcriptomesBMC Genomics, Jan 2014This study establishes CCA as a vital quantitative tool for transcriptome analysis in immunological datasets.
- CD8+ tumor‐infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcomaInternational journal of cancer, Jan 2014
2013
- Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisitionDevelopmental biology, Jan 2013
- Skin disease modeling from a mathematical perspectiveJournal of Investigative Dermatology, Jan 2013
- CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient miceTranslational psychiatry, Jan 2013
- Visualising the cross-level relationships between pathological and physiological processes and gene expression: analyses of haematological diseasesPLoS One, Jan 2013The pioneering study developing Canonical Correspondence Analysis (CCA) as a genomics method, establishing a novel approach for transcriptome analysis.
- Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and DiseaseThe Journal of Immunology, Jan 2013
- Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasisInterface Focus, Jan 2013
2011
- Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiationEur J Immunol, Jan 2011
- Skin barrier homeostasis in atopic dermatitis: feedback regulation of kallikrein activityPLoS One, Jan 2011
- HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In VivoPLOS Pathogens, Feb 2011
- Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanomaBritish Journal of Dermatology, Feb 2011
2009
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription FactorImmunity, Feb 2009
- Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T CellsImmunity, Feb 2009
2008
2007
- Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Nature, Feb 2007
2006
- Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune diseaseImmunological Reviews, Feb 2006
- Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related proteinhigh, Foxp3-expressing CD25+ and CD25− regulatory T cellsThe Journal of Immunology, Feb 2006
2004
- Cutaneous alternariosis in an immunocompetent patient: analysis of the internal transcribed spacer region of rDNA and Brm2 of isolated Alternaria alternataBritish Journal of Dermatology, Feb 2004